Products Description
(CAS: 90347-66-3) Methyl 3-iodo-4-methylbenzoate exhibits high reactivity of the carbon-iodine bond, enabling efficient formation of carbon-carbon bonds in palladium-catalyzed cross-coupling reactions. Moreover, its chlorinated or brominated analogues usually cannot replace it, and it is a crucial intermediate for ensuring the successful synthesis of the drug skeleton.
Products Specification
| Product name | Methyl 3-iodo-4-methylbenzoate |
| CAS NO | 90347-66-3 |
| ITEM NO | M963 |
| Appearance | White to off-white crystalline powder or colorless to yellow liquid |
| Purity | ≥98.0% |
| Refractive index | 1.5975 |
| Package | 100mg/1g/1kg etc. |
| Delivery | 2-3days |
| Storage | 2-8°C(protect from light) |
| MSDS/COA/TDS | Connect us |
Products Application
Methyl 3-iodo-4-methylbenzoate is mainly used in the pharmaceutical industry, serving as a crucial pharmaceutical intermediate for the synthesis of targeted anti-cancer drugs (such as panitumumab and olaparib).
FAQ
Q: What protective measures are needed when operating this?
A: When handling this intermediate, protective gloves, goggles and protective clothing must be worn, and the operation should be carried out in a fume hood to avoid inhaling dust or coming into contact with the skin and eyes.
Q: Why are iodide compounds preferred over bromide compounds in drug synthesis?
A: Because the bond energy of the carbon-iodine bond is lower, the oxidation addition rate in the palladium-catalyzed cross-coupling reaction is faster, the reaction conditions are milder and the efficiency is higher. It is particularly suitable for substrates with large steric hindrance or high electron cloud density that are difficult to react with bromides.
Q: What kind of medicine is it mainly used for synthesis of?
A: Mainly used as a pharmaceutical intermediate, it is employed in the synthesis of various drugs, with a particular focus on targeted anti-cancer drugs. It is also a key precursor for the synthesis of radioactive drugs (used for diagnostic imaging).
Q: Do I need to wear gloves when operating?
A: Required. During operation, protective gloves should be worn. It is also recommended to use goggles and protective clothing to prevent direct skin contact.
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