Products Description
Azido-PEG4-acid is a bifunctional reactive substance: one end of the molecule is the azide group (-N₃), which can be efficiently and specifically linked to alkyne groups, DBCO, etc. through click chemistry; the other end is the carboxyl group (-COOH), which can form stable amide bonds with amino groups of proteins, peptides, etc.
The key feature of Azido-PEG4-acid lies in the PEG4 hydrophilic spacer arm in the middle, which significantly enhances water solubility and reduces steric hindrance, thereby better maintaining the activity of biological macromolecules when constructing PROTAC or ADC drugs.
Products Specification
| Product name | Azido-PEG4-acid/N3-PEG4-COOH/15-Azido-4,7,10,13-tetraoxapentadecanoic acid |
| CAS NO | 1257063-35-6 |
| ITEM NO | M136 |
| Appearance | Colorless to light yellow liquid |
| Purity | 98% |
| Solubility | DMSO：100 mg/mL |
| Package | 10mg/1g/1Kg etc. |
| Delivery | 2-3days |
| Storage | -20°C |
| MSDS/COA/TDS | Connect us |
Products Application
Biomedical Research:Used as bifunctional PEG linker for bioconjugation, protein & peptide modification, drug delivery carrier research.
New Nanomaterials :Applied for nanoparticle surface functionalization, biocompatible material synthesis and fluorescent labeling.
Organic & Biochemical Synthesis : Click chemistry raw material, for molecular tracer synthesis, biolabeling and chemical cross-linking experiments.
The PEG azide series materials that Megma can provide include:
|
Azido-PEG2-acid |
CAS 1312309-63-9 |
|
Biotin-PEG3-Amine |
CAS 359860-27-8 |
|
Azido-PEG4-NHS Ester |
CAS 944251-24-5 |
|
Biotin-PEG3-Azide, 95% |
CAS 875770-34-6 |
|
Biotin-PEG4-Azide, 95% |
CAS 1309649-57-7 |
FAQ
Q: What is the recommended storage condition for this product?
A: Store at -20°C under inert atmosphere, sealed, dry and protected from light. Avoid repeated freeze-thaw cycles.
Q: What solvent is suitable to dissolve Azido-PEG4-acid?
A: It is soluble in water, DCM, DMSO, DMF and other common organic solvents.
Q: Could the azide group of Azido-PEG4-acid be decomposed?
A: Azide group is stable under normal low-temperature dark storage, but it may decompose under strong light, high temperature or heavy metal conditions.
Q: Could this PEG reagent be applied for targeted drug research of lipid nanoparticles?
A: Yes, it can modify the surface of LNP to introduce azide functional groups, facilitating further coupling with targeting ligands
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