Products Description
It has two defined chiral centers. Boc-protected amino group and epoxy ring can undergo ring-opening derivatization. High chiral purity and controllable impurities, suitable for multi-step asymmetric organic synthesis.
Chiral pharmaceutical intermediate with Boc protecting group and epoxy functional group, used in the synthesis and R&D of small molecule drugs such as anti-tumor and protease inhibitors.
Products Specification
| Product name | Carfilzomib intermediate 1/Boc-L-leucine epoxyketone/CarbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl ester |
| CAS NO | 247068-82-2 |
| ITEM NO | M282 |
| Appearance | Off-white solid |
| Purity | ≥98% |
| Chiral Purity | ≥99% |
| Package | 100mg/1g/100kg etc. |
| Delivery | 2-3days |
| Storage | -20℃. |
| MSDS/COA/TDS | Connect us |
Products Application
1. Synthesis of the active pharmaceutical ingredient of carfilzomib: As a key chiral building block for the second-generation proteasome inhibitor carfilzomib, it is used to construct its epoxy ketone warhead structure.
2. Reference standards and quality control: Also used as a reference standard for carfilzomib, it serves for the development of analytical methods (AMV) and quality control (QC) studies.
3. Other drug development: As a chiral intermediate with an epoxy ketone structure, it can also be used for the synthesis of other structurally similar novel proteasome inhibitors.
FAQ
Q: What functional groups are contained in this molecule?
A: It contains Boc-protected amino, ketone carbonyl and epoxy ring, available for de-Boc, epoxy ring-opening and other derivatization reactions.
Q: What is the recommended storage condition?
A: Seal, protect from light and moisture, store at -20℃.
Q: Is this product for clinical use?
A: For research use only, cannot be directly used as finished medicine.
Q: What drug is this intermediate used to synthesize?
A: It is the key chiral intermediate of Carfilzomib, a proteasome inhibitor for multiple myeloma treatment.
Q: What advantages does this chiral building block have for Carfilzomib synthesis?
A: It has predefined dual chiral centers, stable Boc protecting group and epoxy reactive site, which simplifies the subsequent synthetic route.
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