CAS NO:2133298-74-3 Risdiplam Intermediate

CAS NO:2133298-74-3 Risdiplam Intermediate

Molecular Formula:C27H31N7O3
Molecular weight:501.58
Application:Risdiplam is a key synthetic intermediate used in the development of the drug lisofloxacin for the treatment of the rare disease SMA (Spinal Muscular Atrophy).
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Description
Technical Parameters

 

Products Description

 

Risdiplam Intermediate(CAS: 2133298-74-3) is a key advanced intermediate of Risdiplam (Boc-protected type), belonging to the high-end pharmaceutical synthesis building blocks. The molecule has a Boc protection structure, with high structural purity, controllable impurities, and good stability. It is the core process intermediate for preparing the rare disease drug Risdiplam.

 

 

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Products  Specification

 

 

Product name
Risdiplam Intermediate/4,7-Diazaspiro[2.5]octane-4-carboxylic acid, 7-[2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl]-, 1,1-dimethylethyl ester
CAS NO 2133298-74-3
ITEM NO M273
Appearance Bright yellow powder
Purity 99.5%
Density 1.39±0.1 g/cm3(Predicted)
Package 100g/1kg/10kg etc.
Delivery 2-3days
Storage Store at 2-8℃ in a sealed and dark environment for drying.
MSDS/COA/TDS Connect us

 

Products Application

 

 

Mainly used for the synthesis of Risdiplam, a drug for treating spinal muscular atrophy (SMA). It is applicable for the research and development of pharmaceutical intermediates, process optimization, and the large-scale production of raw materials.

 

product-2800-3493

 

 

 

FAQ

 

Q: How to get Risdiplam from this intermediate?

A: Remove Boc‑group under acidic condition followed by purification to obtain Risdiplam API.

Q: Is 2133298‑74‑3 a key intermediate for Risdiplam?

A: Yes, it is the key late‑stage Boc‑protected intermediate for synthesizing Risdiplam API.

Q: What are the storage requirements for Risdiplam Boc‑protected intermediate?

A: Store sealed at 2‑8°C, keep dry, away from acid and light.

Q: Could CAS 2133298‑74‑3 degrade under acidic conditions?

A: Yes, it is acid‑sensitive and will degrade via Boc‑deprotection in acidic environment.

 

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