Products Description
High selectivity of the target: It has extremely strong inhibitory activity against ATR and weak inhibitory effect on most other kinases, with low off-target effects. The experimental data is reliable.
Good oral bioavailability, suitable for cell experiments and in vivo efficacy models in animals, suitable for single drug or combination drug (chemotherapy, PARP inhibitors) research.
Clear mechanism of action, targeting the DNA replication stress damage pathway, widely used in scientific research on tumor cell cycle and DNA repair.
Products Specification
| Product name | AZD6738/Ceralasertib |
| CAS NO | 1352226-88-0 |
| ITEM NO | M180 |
| Appearance | Pale yellow to khaki powder |
| Purity | 99% |
| Melting point | 222 °C |
| Package | 100mg/1g/25g etc. |
| Delivery | 2-3days |
| Storage | -20°C |
| MSDS/COA/TDS | Connect us |
Products Application
1.Anti-cancer drug development: This is its core application area. As a highly selective ATR kinase inhibitor, it is widely used in preclinical research and clinical trials to assess its potential in treating various advanced solid tumors and hematological cancers.
2.Research tools: In basic research, it is also an important research reagent in fields such as molecular biology and pharmacology. Scientists utilize it to explore the mechanism of ATR kinase, the process of DNA damage repair, and new cancer treatment strategies.
FAQ
Q: What are the main target sites and signaling pathways of AZD6738?
A: The main target of AZD6738 is the ataxia telangiectasia mutated (ATM) protein and the Rad3-related protein (ATR) kinase. By inhibiting their activity, it blocks the phosphorylation of the downstream CHK1 protein, thereby interfering with signal pathways such as DNA damage repair and cell cycle checkpoints.
Q: Under the storage condition of -20°C, approximately how long is its shelf life?
A: Powder/freeze-dried powder form: Generally, it can be stored stably for 2 to 3 years.
After being dissolved in a solvent: The stability will decrease. It is recommended to use it within 1 to 6 months.
Q: Is it necessary to maintain a low temperature for transporting this sample?
A: Solid powder is stable during short-term transportation at room temperature and does not require dry ice; for long-term storage, it needs to be kept at -20℃. In summer with high temperatures, it is recommended to use ice packs for transportation assistance, and the prepared solution must be transported under low-temperature cold chain conditions.
Q: May I visit your factory?
A: Welcome to visit! Please make an advance reservation to facilitate our reception and safety arrangements.
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